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Individuals with digestive system conditions including Crohns disease, celiac disease, or a history of gastrointestinal surgery often have difficulty absorbing B12 orally, regardless of diet
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5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT) by binding the enzymes active site
This complex process means that conditions affecting the stomach or intestines can significantly impair B12 absorption, including pernicious anaemia, atrophic gastritis, previous gastric surgery, coeliac disease, Crohn's disease, and long-term use of certain medications (such as metformin, proton pump inhibitors, and H2 antagonists)